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Description:
Stizm™ - Extreme Energy Inducing Formula™
Serving Size: 2 Capsules
Servings per Container: 45
Amount per Serving:
| Caffeine |
250mg |
| Theobromine |
200mg |
| Synephrine HCL |
100mg |
| Octopamine |
100mg |
| Hordenine |
100mg |
| Tyramine HCL |
100mg |
| Phenylethylamine |
50mg |
Suggested Use:
As an adult dietary supplement take two capsules with 8 ounces of water 30-45 minutes before your workout or whenever
an increase in energy or mental clarity is desired.
STIZM™ - Extreme Energy Inducing Formula™ is the most powerful
and effective legal stimulant your money can buy. One look at the ingredient list and that fact becomes crystal clear.
If you are looking for a supplement to boost energy levels beyond anything you have ever experienced before look no further,
Stizm - Extreme Energy Inducing Formula has arrived. Order yours today, supplies are limited. Stizm can be stacked with
Dicana for dramatic weight loss.
Stizm is a serious stimulant and not for the faint of heart. Please
read all warnings before use.
Caffeine
Caffeine is the most consumed drug in the world. Chemically, caffeine is 1,3,7-trimethylxanthine -- meaning it is a
xanthine molecule with methyl groups replacing all of the three hydrogens bound to nitrogens in the xanthine ring. Xanthines
are very potent antioxidants and in numerous studies they have proven to have great potency in protecting cells from
oxidative damage.
Of the 3 xanthines, caffeine is the one with the strongest action on the CNS. It’s mechanism of action is primarily
due to antagonism of adenosine and secondly due to inhibition of the phosphodiesterase enzyme which breaks up cAMP into
adenosine and monophosphoric acid. Caffeine's antagonism of adenosine action on A2A receptors decreases release of the
inhibitory neurotransmitter GABA. Apart from it’s effect on the CNS, caffeine also is the strongest xanthine in promoting
muscular performance. Majority of published evidence supports the notion that caffeine is ergogenic during prolonged
(> 30 min), moderate intensity (approximately 75 to 80% VO2max) exercise. Suggested mechanisms for this action are
(a) increased myofilament affinity for calcium and/or increased release of calcium from the sarcoplasmic reticulum in
skeletal muscle; (b) cellular actions caused by accumulation of cyclic-3',5'-adenosine monophosphate (cAMP) in various
tissues including skeletal muscle and adipocytes; and (c) cellular actions mediated by competitive inhibition of adenosine
receptors in the central nervous system and somatic cells [2]. Caffeine also promotes lypolisis and thermogenesis[3,4,5,6].
It’s effects on BP are mixed, since the CNS stimulation increases BP while the peripheral vasolidation decreases BP.
Chronic caffeine consumption hasn’t shown to be a risk factor for hypertension or CVS disease[7,8].
Theobromine
Unlike caffeine which is naturally present in many plants, theobromine exists almost exclusively in cocoa. It generally
has a much weaker effect on the CNS than caffeine but current research shows that it might play an important role in
the mood-enhancing effects of chocolate[9] It is however a very potent diuretic which can rapidly lower blood pressure,
increase insulin sensitivity[10,11] and has an antiplatelet and cardioprotective effect[12]
Synephrine
 
Synephrine is naturally found in the Citrus aurantium plants. A wide variety of citrus materials containing synephrine
are used in Chinese medicine and have generally been regarded as non-toxic; [13,14]Synephrine is a direct alpha and beta
adrenergic agonist, differing from adrenaline only in the lack of the m-hydroxyl group. This results in greater action
in the CNS than adrenaline, since it makes the molecule less hydrophilic and more capable of bypassing the blood brain
barrier. Also it means that Synephrine has an extended half-life in comparison to adrenaline, as it cannot be metabolized
by COMT . The methyl substitution at the N molecule gives synephrine equal alpha and beta agonistic action. Testing showed
that when given by i.v. infusion to healthy volunteers at a rate of 4 mg/minute, synephrine increases systolic and mean
arterial blood pressure, increases cardiac index, and decreases peripheral vascular resistance resulting in enhanced
heart performance[15]
Tyramine
Tyramine is a trace amine found naturally in the body, as well as many "old" foods, like salami, cheese, red wine, e.t.c.
Tyramine acts by replacing catecholamins like adrenaline and dopamine in the post-senaptic neurons, thus resulting in
catecholamine release.[16] Recent research indicates that tyramine might also act as a neurotransmitter. This hypothesis
comes from the discovery of a G protein-coupled receptor with high affinity for tyramine called TA1[17]
Octopamine
Just like synephrine which stands apart from adrenaline only due the reduction of an –OH group, octopamine is almost
similar to noradrenalin, with the exclusion of a phenolic hydroxyl group. This makes the molecule more capable to bypass
the blood brain barrier and affect the C.N.S. compared to normal noradrenalin. Also the lack of a methyl group at the
nitrogen, gives it equal alpha and beta adrenergic properties. Because it lacks the m-placed hydroxyl group, octopamine,
like synephrine, isn’t metabolized by COMT, thus having a longer half-life and bioavailability. Indeed, in animal in-vivo
studies oral octopamine has demonstrated capability to stimulate both alpha and beta adrenergic receptors(18,19). However
it quite selectively stimulates beta-3 adrenergic receptors, which promote lipolysis, instead of beta-1 and beta-2 receptors[20,21,22].
In animal studies, octopamine has also demonstrated capability to elevate mood, increase blood pressure and enhance locomotor
activity[23,24]
Hordenine
Hordenine is a naturally present amine in many roots of plants of the Graminae family. The lack of a hydroxyl group
in the carbon chain gives it indirect sympathomemetic abilities, like amphetamine. The dymethylation of the nitrogen
atom also gives it slight MAO inhibiting properties, but hordenine seems to be a selective MAO-B inhibitor. MAO-B metabolizes
dopamine and thus it’s inhibition has no great effect in blood pressure, but can elevate mood. Experiments in intact
animals (rats, dogs) show that hordenine has a positive inotropic effect upon the heart, increases systolic and diastolic
blood pressure, peripheral blood flow volume, inhibits gut movements but has no effect upon the psychomotorical behaviour
of mice. Also hordenine is a very potent diuretic and although it can initially heighten blood pressure, over time it’s
diuretic effect lowers blood pressure.[25]
Phenylethylamine(PEA)
 Of all the endogenous trace amines, phenylethylamine is the one most closely structural to amphetamine.
It is a major psychotropic constituent of chocolate and is speculated to be released in great amounts by the brain when
in love[16]. Recent research has identified 15 members of two distinct families of G protein-coupled receptors with a
high degree of similarity to traditional G protein-coupled biogenic amine receptors. It was demonstrated that one of
these receptors, called TA1, is a receptor for two of the trace amines, â-phenylethylamine and tyramine. TA1 binds to
both â-phenylethylamine and tyramine with high affinity and produces cAMP in response to this binding, whereas the related
TA2 receptor appears to be specific for â-phenylethylamine and tryptamine. Both of these G protein-coupled receptor families
possess many of the structural hallmarks of the rhodopsin/â-adrenergic receptor superfamily[17]. Apart from affecting
it’s own receptors, phenylethylamine can also enhance the impulse-propagation mediated release of catecholamine and serotonin[26],
although research has indicated that tryptamine possesses greater capability of promoting serotonin release(thus elevating
mood) while PEA promotes noradrenaline release(thus stimulating the CNS). Phenylethylamine has shown in research to elevate
mood [27,28,29,30] but the biggest challenge has been it’s relatively low half life, since it is rapidly metabolized
by MAO-B. However the inclusion of a MAO-B inhibitor like hordenine can lengthen it’s half-life and effectiveness.[31]
Warning: Not intended for use by anyone under the age of
18. Do not use this product if you are pregnant, nursing or contemplating pregnancy. Do not use this product if you have
any medical condition especially heart disease, thyroid disease, diabetes, high blood pressure, psychiatric condition,
difficulty in urinating, prostate enlargement, or seizure disorder, if you are using a monoamine oxidase inhibitor (MAOI)
or any other prescription drug, or you are using an over-the-counter drug containing ingredients found in certain allergy,
asthma, cough/cold and weight control products.
The recommended dose of this product contains caffeine and should
not be taken by individuals wishing to eliminate caffeine from their diet. Limit use of caffeine-containing foods and
beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and
occasionally, rapid heartbeat.
Exceeding recommended serving will not improve results.
Discontinue use and call a health care professional immediately
if you experience rapid heartbeat, dizziness, severe headache, shortness of breath, or other similar symptoms.
- PHAMACOLOGICAL REVIEWS 51(1):83-133 (1999) http://pharmrev.aspetjournals.org/cgi/content/abstract/51/1/83
- Sports Med. 1993 Jan;15(1):14-23. Caffeine and exercise performance. An update.
- Metabolic effects of caffeine in humans: lipid oxidation or futile cycling? Am J Clin Nutr. 2004 Jan;79(1):40-6.
- Effects of caffeine ingestion on NE kinetics, fat oxidation, and energy expenditure in younger and older men. Am
J Physiol. 1995 Jun;268(6 Pt 1):E1192-8.
- Pharmacology of thermogenic drugs.
- Effects of caffeine ingestion on metabolism and exercise performance.
- THE NEW ENGLAND JOURNAL OF MEDICINE 323:1026-1032 (1990)
- Title Habitual caffeine intake and the risk of hypertension in women.Winkelmayer, WC; Stampfer, MJ; Willett, WC;
Curhan, GC
- Fraga CG. Cocoa, diabetes, and hypertension: should we eat more chocolate? Am J Clin Nutr 2005;81:541-2(editorial).
- 1. Grassi D, Lippi C, Necozione S, Desideri G, Ferri C. Short-term administration of dark chocolate is followed
by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons.AmJ Clin Nutr 2005;81:611-
4.
- Fraga CG. Cocoa, diabetes, and hypertension: should we eat more chocolate? Am J Clin Nutr 2005;81:541-2(editorial).
- Cocoa inhibits platelet activation and function1,2 Dietrich Rein, Teresa G Paglieroni, Ted Wun, Debra A Pearson,
Harold H Schmitz, Robert Gosselin, and Carl L Keen
- Usio Sankawa and Chun Yuito, Anti-allergic substances from Chinese Medicinal Plants, in Advances in Chinese Medicinal
Materials Research, 171-180.
- Miyamoto K, Abdu P, and Furukawa T, Pharmacological effects of chenpi and synephrine, International Journal of Oriental
Medicine 1990; 15(2): 57-69.
- Hofstetter R, Kreuder J, von Bernuth G, The effect of oxedrine on the left ventricle and peripheral vascular resistance,
Arzneimittelforschung 1985; 35(12): 1844-1846 [German].
- PHENYLETHYLAMINE AND TYRAMINE ARE MIXED ACTING SYMPATHOMIMETIC AMINES IN THE BRAIN Joseph Knoll, Ildik6 Miklya,
Berta Knoll, Raissa Marki, and Daniel ticz
- Following the trace of elusive amines Richard T. Premont, Raul R. Gainetdinov, and Marc G. Caron* Howard Hughes
Medical Institute, Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, NC 27710 http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=11504935
- Axelrod J, Saavedra J M. Nature (London). 1977;265:501–504
- J Dent Res. 1993 Jun;72(6):993-1000. The effects of p-octopamine on salivary flow rates and protein secretion by
rat submandibular glands. Okina A, Abe K, Tashiro M, Ishibashi K.
- Comp Biochem Physiol C Toxicol Pharmacol. 2000 Jan;125(1):33-44. Effects of octopamine on lipolysis, glucose transport
and amine oxidation in mammalian fat cells. Fontana E, Morin N, Prevot D, Carpene C.
- Naunyn Schmiedebergs Arch Pharmacol. 1999 Apr;359(4):310-21. Selective activation of beta3-adrenoceptors by octopamine:
comparative studies in mammalian fat cells. Carpene C, Galitzky J, Fontana E, Atgie C, Lafontan M, Berlan M.
- C R Acad Sci III. 1993;316(5):519-23. [Specific stimulation of adipose tissue adrenergic beta 3 receptors by octopamine]
[Article in French] Galitzky J, Carpene C, Lafontan M, Berlan M.
- Clin Invest Med. 1988 Dec;11(6):396-402. Effects of octopamine on renal function in anaesthetized dogs. Levy M.
- J Pharmacol. 1984 Jan-Mar;15(1):1-15. [Antidepressive effects of 3 endogenous monoamines: psychopharmacologic profiles
of noradrenaline, octopamine and phenethylamine] [Article in French] Bulach C, Doare L, Massari B, Simon P.
- Pharmacological Effects of Hordenine. Hapke HJ, Strathmann,W
- Knoll et al., 1999; Knoll, 2003).
- Greenshaw, 1989;
- Davis and Boulton, 1994;
- Sabelli and Javaid, 1995;
- Sabelli et al., 1986, 1996; Premont et al.,2001).
- Pharmacological studies with endogenous enhancer substances: h-phenylethylamine, tryptamine, and their synthetic
derivatives Seiichiro Shimazua,*, Ildiko´ Miklyab
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